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Alprazolam, also known under the trade names Xanax (not to be confused with Zantac), Xanor, Alprax, and Niravam, is a short-acting drug of the benzodiazepine class. It is primarily used to treat moderate to severe anxiety disorders and panic attacks, and is used as an adjunctive treatment for anxiety associated with moderate depression. It is also available in an extended-release form, Xanax XR, both of which are now available in generic form. Alprazolam possesses anxiolytic, sedative, hypnotic, anticonvulsant, and muscle relaxant properties.
Xanax has a fast onset of symptom relief (within the first week), it is unlikely to produce dependency or abuse. Tolerance to the therapeutic effects of Xanax is controversial with one view being that Xanax is ineffective with long term use and the other view being that tolerance to the therapeutic effects does not occur. At discontinuation of Xanax treatment, withdrawal and rebound symptoms are common. Hence, Xanax discontinuation must be tapered. Withdrawal symptoms similar in character to those noted with sedative-hypnotics and alcohol have occurred following discontinuance of benzodiazepines, including Alprazolam. The symptoms can range from mild dysphoria and insomnia to a major syndrome that may include abdominal and muscle cramps, vomiting, sweating, tremors and convulsions.
Alprazolam was first synthesized by Upjohn (now a part of Pfizer). It is covered under U.S. Patent 3,987,052, which was filed on October 29, 1969, granted on October 19, 1976 and expired in September 1993. Alprazolam was released in 1981. The first approved indication was panic disorder. Upjohn took this direction at the behest of a young psychiatrist David Sheehan. Sheehan's suggestion was to use the new distinction the DSM-III created in the classification of anxiety disorders between generalized anxiety disorder (GAD) and panic disorder in order to market Alprazolam specifically for the latter. Panic disorder was, at that point, perceived to be rare and treatable only with tricyclic antidepressants; benzodiazepines were thought to be ineffective. However, from his clinical experience, Sheehan knew panic disorder to be both widespread among the populace and responsive to benzodiazepines. He suggested to Upjohn that marketing alprazolam for panic disorder would both cover new diagnostic territory and emphasize the unique potency of this drug. Sheehan describes that the first group of patients treated by Alprazolam was so impressed by its action that the company knew outright that this drug was going to be a hit. A few of those patients actually pooled their money and purchased stock in Upjohn. Several months later, when Alprazolam was approved by the United States Food and Drug Administration, they sold out and made a profit
Xanax is a tranquilizer used in the short-term relief of symptoms of anxiety or the treatment of anxiety disorders. It is sometimes prescribed for treatment of alcohol withdrawal, fear of open spaces and strangers, depression, irritable bowel syndrome and premenstrual syndrome.
How to take Xanax
Follow the directions for using Xanax provided by your doctor. Xanax may be taken with or without food. If stomach upset occurs, take with food to reduce stomach irritation. Avoid eating grapefruit or drinking grapefruit juice while you are being treated with Xanax.
Xanax Side effects
Xanax No Prescription Side effects, that may go away during treatment, include excessive daytime drowsiness, unusual weakness, dizziness, lightheadedness, headache, clumsiness, or unsteadiness. If they continue or are bothersome, check with your doctor. If you notice other effects not listed above, contact your doctor, nurse, or pharmacist.
Do not exceed the recommended dose or take Xanax No Prescription for longer than prescribed. Exceeding the recommended dose or taking Xanax for longer than prescribed may be habit-forming. This medicine may cause drowsiness or dizziness. Do not drive, operate machinery, or do anything else that could be dangerous until you know how you react to this medicine. Xanax will add to the effects of other medicines and alcohol. Ask your pharmacist if you have questions about which medicines can cause drowsiness. For women: Xanax has been shown to cause harm to the human fetus. If you plan on becoming pregnant, discuss with your doctor the benefits and risks of using Xanax during pregnancy. Xanax is excreted in breast milk. Do not breast-feed while taking this medicine. Tell your doctor or pharmacist if you have any medical conditions. Some medical conditions may interact with Xanax: if you have glaucoma or a predisposition for glaucoma, liver problems, lung problems or chronic obstructive pulmonary disease (COPD), muscle problems, depression, suicidal tendencies, a blood disorder known as porphyria, or a history of substance abuse or dependence.
Additional Xanax Precautions
Do not use Xanax No Prescription if you have:
Xanax Drug interactions
Some medicines may interact with Xanax. Tell your health care provider if you are taking any other medicines, especially any of the following: Rifampin or St. John's wort because the effectiveness of Xanax may be decreased; Azole antifungals (eg, itraconazole, ketoconazole), cimetidine, clozapine, delavirdine, fluvoxamine, HIV protease inhibitors (eg, ritonavir), fluoxetine, macrolides and ketolides (eg, erythromycin, azithromycin), nefazodone, omeprazole, propoxyphene, sodium oxybate (GHB), or valproic acid because side effects such as increased sedation or heart problems may occur; Clozapine, hydantoins (eg, phenytoin), or valproic acid because the actions and side effects of these medicines may be increased. This may not be a complete list of all interactions that may occur. Ask your health care provider if Xanax may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.
If you miss a dose of Xanax and you are using it regularly, take it as soon as possible. If you do not remember until later, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.
Storage of Xanax
Store Xanax at room temperature between 59 and 86 degrees F (15-30 degrees C) away from light and moisture. Keep this and all medications out of the reach of children.